Y81F (p.Tyr81Phe) variant of MFN2 (Mitofusin-2)
Y81F (p.Tyr81Phe) in MFN2 (Mitofusin-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
Y81F (p.Tyr81Phe) variant details
- p.Tyr81Phe
- TOPMed rs1638737706
- Missense
- Variant Prioritization Score for Impact Estimate 0.549
- REVEL 0.58
- CADD 22.60
- PolyPhen-2 0.03
- SIFT 0.26
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available