Y59C (p.Tyr59Cys) variant of MERTK (Tyrosine-protein kinase Mer)
Y59C (p.Tyr59Cys) in MERTK (Tyrosine-protein kinase Mer) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data, published literature, and structural context.
Y59C (p.Tyr59Cys) variant details
- p.Tyr59Cys
- gnomAD 2-111929234-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.201
- REVEL 0.13
- MetaLR 0.20
- MetaSVM -0.91
- CADD 17.60
- PolyPhen-2 0.19
- SIFT 0.12
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available