W18C (p.Trp18Cys) variant of MERTK (Tyrosine-protein kinase Mer)
W18C (p.Trp18Cys) in MERTK (Tyrosine-protein kinase Mer) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
W18C (p.Trp18Cys) variant details
- p.Trp18Cys
- ExAC rs745681896
- gnomAD rs745681896
- Missense
- Variant Prioritization Score for Impact Estimate 0.364
- REVEL 0.24
- MetaLR 0.21
- MetaSVM -0.86
- CADD 14.90
- PolyPhen-2 0.25
- SIFT 0.10
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available