T45I (p.Thr45Ile) variant of MERTK (Tyrosine-protein kinase Mer)
T45I (p.Thr45Ile) in MERTK (Tyrosine-protein kinase Mer) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
T45I (p.Thr45Ile) variant details
- p.Thr45Ile
- TOPMed rs1684622606
- gnomAD rs1684622606
- Missense
- Variant Prioritization Score for Impact Estimate 0.134
- REVEL 0.07
- MetaLR 0.16
- MetaSVM -0.98
- CADD 10.60
- SIFT 0.14
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available