L14F (p.Leu14Phe) variant of MERTK (Tyrosine-protein kinase Mer)
L14F (p.Leu14Phe) in MERTK (Tyrosine-protein kinase Mer) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
L14F (p.Leu14Phe) variant details
- p.Leu14Phe
- ExAC rs777333807
- TOPMed rs777333807
- gnomAD rs777333807
- Missense
- Variant Prioritization Score for Impact Estimate 0.221
- REVEL 0.14
- MetaLR 0.20
- MetaSVM -0.93
- CADD 14.60
- PolyPhen-2 0.00
- SIFT 0.02
- Most common in the REMAINING population (allele frequency 3.3e-05)
- Structural context available