G11C (p.Gly11Cys) variant of MERTK (Tyrosine-protein kinase Mer)
G11C (p.Gly11Cys) in MERTK (Tyrosine-protein kinase Mer) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, published literature, and structural context.
G11C (p.Gly11Cys) variant details
- p.Gly11Cys
- gnomAD 2-111898766-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.255
- REVEL 0.18
- MetaLR 0.25
- MetaSVM -0.85
- CADD 24.50
- PolyPhen-2 0.67
- SIFT 0.16
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available