V27I (p.Val27Ile) variant of MDM4 (Protein Mdm4)
V27I (p.Val27Ile) in MDM4 (Protein Mdm4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data, experimental measurements, and structural context.
V27I (p.Val27Ile) variant details
- p.Val27Ile
- Ensembl rs2102321116
- Missense
- Variant Prioritization Score for Impact Estimate 0.399
- REVEL 0.12
- CADD 27.60
- PolyPhen-2 0.51
- SIFT 0.07
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00091)
- Structural context available
- MDM4 Zinc finger, RanBP2-type domain domainome 1.0: score -0.249