T12S (p.Thr12Ser) variant of MDM4 (Protein Mdm4)
T12S (p.Thr12Ser) in MDM4 (Protein Mdm4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, experimental measurements, and structural context.
T12S (p.Thr12Ser) variant details
- p.Thr12Ser
- cosmic curated COSV65798
- TOPMed rs905303517
- gnomAD rs905303517
- Missense
- Variant Prioritization Score for Impact Estimate 0.53
- CADD 10.50
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00019)
- Structural context available
- MDM4 Zinc finger, RanBP2-type domain domainome 1.0: score -0.373