S3T (p.Ser3Thr) variant of MDM4 (Protein Mdm4)
S3T (p.Ser3Thr) in MDM4 (Protein Mdm4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
S3T (p.Ser3Thr) variant details
- p.Ser3Thr
- gnomAD 1-204525525-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.208
- REVEL 0.04
- CADD 18.80
- PolyPhen-2 0.41
- SIFT 0.21
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available
- MDM4 Zinc finger, RanBP2-type domain domainome 1.0: score -0.259
- Literature evidence available