S15T (p.Ser15Thr) variant of MDM4 (Protein Mdm4)
S15T (p.Ser15Thr) in MDM4 (Protein Mdm4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data, experimental measurements, and structural context.
S15T (p.Ser15Thr) variant details
- p.Ser15Thr
- Ensembl rs2102314085
- Missense
- Variant Prioritization Score for Impact Estimate 0.144
- REVEL 0.05
- CADD 16.90
- PolyPhen-2 0.06
- SIFT 0.41
- Most common in the African/African-American population (allele frequency 0.00031)
- Structural context available
- MDM4 Zinc finger, RanBP2-type domain domainome 1.0: score -0.215