P21T (p.Pro21Thr) variant of MDM4 (Protein Mdm4)
P21T (p.Pro21Thr) in MDM4 (Protein Mdm4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.05 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P21T (p.Pro21Thr) variant details
- p.Pro21Thr
- cosmic curated COSV10592
- TOPMed rs1481232207
- gnomAD rs1481232207
- Missense
- Variant Prioritization Score for Impact Estimate 0.0533
- REVEL 0.04
- CADD 0.07
- PolyPhen-2 0.00
- SIFT 0.84
- Most common in the 1KG:CLM population (allele frequency 0.0053)
- Structural context available
- MDM4 Zinc finger, RanBP2-type domain domainome 1.0: score -0.285