P21S (p.Pro21Ser) variant of MDM4 (Protein Mdm4)
P21S (p.Pro21Ser) in MDM4 (Protein Mdm4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.05 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P21S (p.Pro21Ser) variant details
- p.Pro21Ser
- cosmic curated COSV10442
- TOPMed rs1481232207
- gnomAD rs1481232207
- Missense
- Variant Prioritization Score for Impact Estimate 0.0485
- REVEL 0.03
- CADD 0.07
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the HGDP:YAKUT population (allele frequency 0.04)
- Structural context available
- MDM4 Zinc finger, RanBP2-type domain domainome 1.0: score -0.285