P21A (p.Pro21Ala) variant of MDM4 (Protein Mdm4)
P21A (p.Pro21Ala) in MDM4 (Protein Mdm4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.04 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P21A (p.Pro21Ala) variant details
- p.Pro21Ala
- TOPMed rs1481232207
- gnomAD rs1481232207
- Missense
- Variant Prioritization Score for Impact Estimate 0.0374
- REVEL 0.02
- CADD 0.15
- PolyPhen-2 0.00
- SIFT 0.45
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available
- MDM4 Zinc finger, RanBP2-type domain domainome 1.0: score -0.285