N25S (p.Asn25Ser) variant of MDM4 (Protein Mdm4)
N25S (p.Asn25Ser) in MDM4 (Protein Mdm4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
N25S (p.Asn25Ser) variant details
- p.Asn25Ser
- gnomAD 1-204525592-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.0739
- REVEL 0.03
- CADD 9.15
- PolyPhen-2 0.00
- SIFT 0.52
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available
- MDM4 Zinc finger, RanBP2-type domain domainome 1.0: score -1
- Literature evidence available