I19S (p.Ile19Ser) variant of MDM4 (Protein Mdm4)
I19S (p.Ile19Ser) in MDM4 (Protein Mdm4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data, experimental measurements, and structural context.
I19S (p.Ile19Ser) variant details
- p.Ile19Ser
- TOPMed rs1185480236
- gnomAD rs1185480236
- Missense
- Variant Prioritization Score for Impact Estimate 0.195
- REVEL 0.07
- CADD 22.00
- PolyPhen-2 0.00
- SIFT 0.15
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available
- MDM4 Zinc finger, RanBP2-type domain domainome 1.0: score -0.355