A16P (p.Ala16Pro) variant of MDM4 (Protein Mdm4)
A16P (p.Ala16Pro) in MDM4 (Protein Mdm4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, experimental measurements, and structural context.
A16P (p.Ala16Pro) variant details
- p.Ala16Pro
- ExAC rs780902661
- Missense
- Variant Prioritization Score for Impact Estimate 0.278
- REVEL 0.14
- CADD 24.70
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available
- MDM4 Zinc finger, RanBP2-type domain domainome 1.0: score -0.209