T10T (p.Thr10Thr) variant of MDM2 (E3 ubiquitin-protein ligase Mdm2)
T10T (p.Thr10Thr) in MDM2 (E3 ubiquitin-protein ligase Mdm2) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
T10T (p.Thr10Thr) variant details
- p.Thr10Thr
- gnomAD 12-68809223-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.689
- CADD 16.20
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available
- MDM2 Zinc finger, RanBP2-type domain domainome 1.0: score -0.0373
- Literature evidence available