T10S (p.Thr10Ser) variant of MDM2 (E3 ubiquitin-protein ligase Mdm2)
T10S (p.Thr10Ser) in MDM2 (E3 ubiquitin-protein ligase Mdm2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, experimental measurements, and structural context.
T10S (p.Thr10Ser) variant details
- p.Thr10Ser
- cosmic curated COSV10585
- NCI-TCGA Cosmic COSV9925
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.303
- REVEL 0.08
- CADD 24.40
- PolyPhen-2 0.12
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available
- MDM2 Zinc finger, RanBP2-type domain domainome 1.0: score -0.0373