T10N (p.Thr10Asn) variant of MDM2 (E3 ubiquitin-protein ligase Mdm2)
T10N (p.Thr10Asn) in MDM2 (E3 ubiquitin-protein ligase Mdm2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
T10N (p.Thr10Asn) variant details
- p.Thr10Asn
- gnomAD 12-68809222-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.388
- REVEL 0.10
- CADD 25.50
- PolyPhen-2 0.55
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- MDM2 Zinc finger, RanBP2-type domain domainome 1.0: score -0.0373
- Literature evidence available