S22S (p.Ser22Ser) variant of MDM2 (E3 ubiquitin-protein ligase Mdm2)
S22S (p.Ser22Ser) in MDM2 (E3 ubiquitin-protein ligase Mdm2) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
S22S (p.Ser22Ser) variant details
- p.Ser22Ser
- gnomAD 12-68809262-A-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.184
- CADD 14.60
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available
- MDM2 Zinc finger, RanBP2-type domain domainome 1.0: score -0.0771
- Literature evidence available