P20L (p.Pro20Leu) variant of MDM2 (E3 ubiquitin-protein ligase Mdm2)
P20L (p.Pro20Leu) in MDM2 (E3 ubiquitin-protein ligase Mdm2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
P20L (p.Pro20Leu) variant details
- p.Pro20Leu
- rs201821879
- gnomAD 12-68809237-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.345
- REVEL 0.06
- CADD 22.80
- PolyPhen-2 0.00
- SIFT 0.19
- Population evidence available
- Structural context available
- MDM2 Zinc finger, RanBP2-type domain domainome 1.0: score -0.146
- Literature evidence available