E25K (p.Glu25Lys) variant of MDM2 (E3 ubiquitin-protein ligase Mdm2)
E25K (p.Glu25Lys) in MDM2 (E3 ubiquitin-protein ligase Mdm2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
E25K (p.Glu25Lys) variant details
- p.Glu25Lys
- rs1361311287
- gnomAD 12-68809278-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.366
- REVEL 0.11
- AlphaMissense 0.20
- MetaLR 0.33
- MetaSVM -0.30
- CADD 32.00
- PolyPhen-2 0.92
- Population evidence available
- Structural context available
- MDM2 Zinc finger, RanBP2-type domain domainome 1.0: score 0.204
- Literature evidence available