E25G (p.Glu25Gly) variant of MDM2 (E3 ubiquitin-protein ligase Mdm2)
E25G (p.Glu25Gly) in MDM2 (E3 ubiquitin-protein ligase Mdm2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
E25G (p.Glu25Gly) variant details
- p.Glu25Gly
- rs746439458
- gnomAD 12-68809285-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.413
- REVEL 0.21
- CADD 32.00
- PolyPhen-2 0.97
- SIFT 0.03
- Population evidence available
- Structural context available
- MDM2 Zinc finger, RanBP2-type domain domainome 1.0: score 0.204
- Literature evidence available