Y84C (p.Tyr84Cys) variant of MCM6 (Q14566)
Y84C (p.Tyr84Cys) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data and structural context.
Y84C (p.Tyr84Cys) variant details
- p.Tyr84Cys
- ExAC rs771924466
- TOPMed rs771924466
- gnomAD rs771924466
- Missense
- Variant Prioritization Score for Impact Estimate 0.622
- REVEL 0.57
- CADD 32.00
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available