V63A (p.Val63Ala) variant of MCM6 (Q14566)
V63A (p.Val63Ala) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
V63A (p.Val63Ala) variant details
- p.Val63Ala
- ExAC rs758646175
- gnomAD rs758646175
- Missense
- Variant Prioritization Score for Impact Estimate 0.611
- REVEL 0.58
- CADD 27.40
- PolyPhen-2 0.92
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available