T135S (p.Thr135Ser) variant of MCM6 (Q14566)
T135S (p.Thr135Ser) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
T135S (p.Thr135Ser) variant details
- p.Thr135Ser
- ExAC rs754500820
- Missense
- Variant Prioritization Score for Impact Estimate 0.36
- REVEL 0.10
- CADD 22.00
- PolyPhen-2 0.00
- SIFT 0.10
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available