R58S (p.Arg58Ser) variant of MCM6 (Q14566)
R58S (p.Arg58Ser) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
R58S (p.Arg58Ser) variant details
- p.Arg58Ser
- TOPMed rs1165095087
- gnomAD rs1165095087
- Missense
- Variant Prioritization Score for Impact Estimate 0.343
- REVEL 0.28
- CADD 23.90
- PolyPhen-2 0.57
- SIFT 0.08
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available