P56S (p.Pro56Ser) variant of MCM6 (Q14566)
P56S (p.Pro56Ser) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
P56S (p.Pro56Ser) variant details
- p.Pro56Ser
- ExAC rs755569944
- TOPMed rs755569944
- gnomAD rs755569944
- Missense
- Variant Prioritization Score for Impact Estimate 0.474
- REVEL 0.28
- CADD 22.80
- PolyPhen-2 0.10
- SIFT 0.35
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available