L61M (p.Leu61Met) variant of MCM6 (Q14566)
L61M (p.Leu61Met) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
L61M (p.Leu61Met) variant details
- p.Leu61Met
- 1000Genomes rs550021704
- ExAC rs550021704
- TOPMed rs550021704
- gnomAD rs550021704
- Missense
- Variant Prioritization Score for Impact Estimate 0.34
- REVEL 0.33
- CADD 23.20
- PolyPhen-2 0.80
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available