L3F (p.Leu3Phe) variant of MCM6 (Q14566)
L3F (p.Leu3Phe) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
L3F (p.Leu3Phe) variant details
- p.Leu3Phe
- ExAC rs769922920
- gnomAD rs769922920
- Missense
- Variant Prioritization Score for Impact Estimate 0.279
- REVEL 0.11
- CADD 22.40
- PolyPhen-2 0.25
- SIFT 0.07
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available