K25Q (p.Lys25Gln) variant of MCM6 (Q14566)
K25Q (p.Lys25Gln) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
K25Q (p.Lys25Gln) variant details
- p.Lys25Gln
- TOPMed rs1229479030
- gnomAD rs1229479030
- Missense
- Variant Prioritization Score for Impact Estimate 0.338
- REVEL 0.22
- CADD 24.00
- PolyPhen-2 0.04
- SIFT 0.11
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available