K108R (p.Lys108Arg) variant of MCM6 (Q14566)
K108R (p.Lys108Arg) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
K108R (p.Lys108Arg) variant details
- p.Lys108Arg
- TOPMed rs1431157013
- Missense
- Variant Prioritization Score for Impact Estimate 0.352
- REVEL 0.17
- CADD 23.00
- PolyPhen-2 0.13
- SIFT 0.37
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available