I123V (p.Ile123Val) variant of MCM6 (Q14566)
I123V (p.Ile123Val) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
I123V (p.Ile123Val) variant details
- p.Ile123Val
- ExAC rs767727857
- gnomAD rs767727857
- Missense
- Variant Prioritization Score for Impact Estimate 0.367
- REVEL 0.21
- CADD 21.20
- PolyPhen-2 0.01
- SIFT 0.59
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available