I123M (p.Ile123Met) variant of MCM6 (Q14566)
I123M (p.Ile123Met) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
I123M (p.Ile123Met) variant details
- p.Ile123Met
- gnomAD rs1407333908
- Missense
- Variant Prioritization Score for Impact Estimate 0.237
- REVEL 0.17
- CADD 22.90
- PolyPhen-2 0.09
- SIFT 0.03
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available