E36K (p.Glu36Lys) variant of MCM6 (Q14566)
E36K (p.Glu36Lys) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
E36K (p.Glu36Lys) variant details
- p.Glu36Lys
- ExAC rs769402048
- TOPMed rs769402048
- gnomAD rs769402048
- Missense
- Variant Prioritization Score for Impact Estimate 0.425
- REVEL 0.19
- CADD 25.40
- PolyPhen-2 0.14
- SIFT 0.09
- Most common in the Latino/Admixed American population (allele frequency 2.3e-05)
- Structural context available