E35K (p.Glu35Lys) variant of MCM6 (Q14566)
E35K (p.Glu35Lys) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
E35K (p.Glu35Lys) variant details
- p.Glu35Lys
- TOPMed rs1680295695
- Missense
- Variant Prioritization Score for Impact Estimate 0.432
- REVEL 0.21
- CADD 23.90
- PolyPhen-2 0.02
- SIFT 0.16
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available