A4S (p.Ala4Ser) variant of MCM6 (Q14566)
A4S (p.Ala4Ser) in MCM6 (Q14566) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
A4S (p.Ala4Ser) variant details
- p.Ala4Ser
- TOPMed rs1411055513
- gnomAD rs1411055513
- Missense
- Variant Prioritization Score for Impact Estimate 0.381
- REVEL 0.13
- CADD 22.50
- PolyPhen-2 0.14
- SIFT 0.24
- Most common in the Latino/Admixed American population (allele frequency 0.00013)
- Structural context available