W69R (p.Trp69Arg) variant of MCM5 (P33992)
W69R (p.Trp69Arg) in MCM5 (P33992) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
W69R (p.Trp69Arg) variant details
- p.Trp69Arg
- ExAC rs774927495
- gnomAD rs774927495
- Missense
- Variant Prioritization Score for Impact Estimate 0.489
- REVEL 0.51
- MetaLR 0.02
- MetaSVM -1.05
- CADD 23.90
- PolyPhen-2 0.01
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available