P7S (p.Pro7Ser) variant of MCM5 (P33992)
P7S (p.Pro7Ser) in MCM5 (P33992) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
P7S (p.Pro7Ser) variant details
- p.Pro7Ser
- cosmic curated COSV10507
- ExAC rs764150043
- TOPMed rs764150043
- gnomAD rs764150043
- Missense
- Variant Prioritization Score for Impact Estimate 0.325
- REVEL 0.14
- MetaLR 0.10
- MetaSVM -1.02
- CADD 23.10
- PolyPhen-2 0.02
- SIFT 0.24
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available