M74V (p.Met74Val) variant of MCM5 (P33992)
M74V (p.Met74Val) in MCM5 (P33992) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
M74V (p.Met74Val) variant details
- p.Met74Val
- ExAC rs750883580
- gnomAD rs750883580
- Missense
- Variant Prioritization Score for Impact Estimate 0.185
- REVEL 0.09
- MetaLR 0.02
- MetaSVM -1.04
- CADD 19.70
- PolyPhen-2 0.00
- SIFT 0.22
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available