D22V (p.Asp22Val) variant of MCM5 (P33992)
D22V (p.Asp22Val) in MCM5 (P33992) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
D22V (p.Asp22Val) variant details
- p.Asp22Val
- gnomAD rs1422590605
- Missense
- Variant Prioritization Score for Impact Estimate 0.341
- REVEL 0.28
- MetaLR 0.14
- MetaSVM -0.87
- CADD 25.60
- PolyPhen-2 0.10
- SIFT 0.14
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available