T25I (p.Thr25Ile) variant of MCM2 (P49736)
T25I (p.Thr25Ile) in MCM2 (P49736) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
T25I (p.Thr25Ile) variant details
- p.Thr25Ile
- ExAC rs750028509
- gnomAD rs750028509
- Missense
- Variant Prioritization Score for Impact Estimate 0.252
- REVEL 0.06
- MetaLR 0.10
- MetaSVM -0.90
- CADD 23.50
- PolyPhen-2 0.51
- SIFT 0.19
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available