S7Y (p.Ser7Tyr) variant of MCM2 (P49736)
S7Y (p.Ser7Tyr) in MCM2 (P49736) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
S7Y (p.Ser7Tyr) variant details
- p.Ser7Tyr
- TOPMed rs2074287101
- Missense
- Variant Prioritization Score for Impact Estimate 0.347
- REVEL 0.13
- MetaLR 0.01
- MetaSVM -0.67
- CADD 25.30
- PolyPhen-2 0.56
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available