S27G (p.Ser27Gly) variant of MCM2 (P49736)
S27G (p.Ser27Gly) in MCM2 (P49736) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
S27G (p.Ser27Gly) variant details
- p.Ser27Gly
- gnomAD rs1359617924
- Missense
- Variant Prioritization Score for Impact Estimate 0.311
- REVEL 0.17
- MetaLR 0.12
- MetaSVM -0.95
- CADD 25.20
- PolyPhen-2 0.83
- SIFT 0.07
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available