R34C (p.Arg34Cys) variant of MCM2 (P49736)
R34C (p.Arg34Cys) in MCM2 (P49736) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
R34C (p.Arg34Cys) variant details
- p.Arg34Cys
- ExAC rs758941392
- TOPMed rs758941392
- gnomAD rs758941392
- Missense
- Variant Prioritization Score for Impact Estimate 0.32
- REVEL 0.21
- MetaLR 0.11
- MetaSVM -0.87
- CADD 26.30
- PolyPhen-2 0.64
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 8.1e-06)
- Structural context available