R19G (p.Arg19Gly) variant of MCM2 (P49736)
R19G (p.Arg19Gly) in MCM2 (P49736) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, published literature, and structural context.
R19G (p.Arg19Gly) variant details
- p.Arg19Gly
- gnomAD 3-127599366-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.159
- REVEL 0.06
- MetaLR 0.08
- MetaSVM -1.00
- CADD 19.70
- PolyPhen-2 0.00
- SIFT 0.08
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available