P62T (p.Pro62Thr) variant of MCM2 (P49736)
P62T (p.Pro62Thr) in MCM2 (P49736) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
P62T (p.Pro62Thr) variant details
- p.Pro62Thr
- gnomAD rs1175630953
- Missense
- Variant Prioritization Score for Impact Estimate 0.274
- REVEL 0.05
- MetaLR 0.05
- MetaSVM -1.10
- CADD 20.50
- PolyPhen-2 0.13
- SIFT 0.49
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available