P23S (p.Pro23Ser) variant of MCM2 (P49736)
P23S (p.Pro23Ser) in MCM2 (P49736) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data, published literature, and structural context.
P23S (p.Pro23Ser) variant details
- p.Pro23Ser
- gnomAD 3-127599378-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.268
- REVEL 0.03
- MetaLR 0.05
- MetaSVM -1.07
- CADD 22.50
- PolyPhen-2 0.00
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available