L38F (p.Leu38Phe) variant of MCM2 (P49736)
L38F (p.Leu38Phe) in MCM2 (P49736) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
L38F (p.Leu38Phe) variant details
- p.Leu38Phe
- Ensembl rs1559859637
- Missense
- Variant Prioritization Score for Impact Estimate 0.163
- REVEL 0.03
- MetaLR 0.06
- MetaSVM -1.07
- CADD 21.00
- PolyPhen-2 0.00
- SIFT 0.21
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available