I73V (p.Ile73Val) variant of MCM2 (P49736)
I73V (p.Ile73Val) in MCM2 (P49736) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
I73V (p.Ile73Val) variant details
- p.Ile73Val
- ExAC rs746153512
- gnomAD rs746153512
- Missense
- Variant Prioritization Score for Impact Estimate 0.236
- REVEL 0.10
- MetaLR 0.05
- MetaSVM -1.10
- CADD 22.70
- PolyPhen-2 0.13
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available